Pyridine → HCID 123639140, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred suspension of 6-fluoro-6,7,8,9-tetrahydrobenzocylohepten-5-one CAS: 127053-30-9 (1.06 g; 5.95 mmol) in methanol (12 ml) was added pyridine (1.53 ml; 19.04 mmol) followed by a portionwise addition of methoxyamine hydrochloride (1.59 g; 19.04 mmol). The reaction mixture was stirred at 20° C. for 16 h under nitrogen. The solvent was removed in vacuo to afford 1.28 g (100% of theory) of crude 6-fluoro-6,7,8,9-tetrahydrobenzocylohepten-5-one-O-methyl-oxime E/Z-mixture as a brown oil.

Provenance & Evidence