Pyridine → HCID 123639140, compound
Reaction equation
[F:1][CH:2]1[CH2:8][CH2:7][CH2:6][C:5]2[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=2[C:3]1=O.N1C=CC=CC=1.Cl.[CH3:21][O:22][NH2:23]>CO>[CH3:21][O:22][N:23]=[C:3]1[C:4]2[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=2[CH2:6][CH2:7][CH2:8][CH:2]1[F:1]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
To a stirred suspension of 6-fluoro-6,7,8,9-tetrahydrobenzocylohepten-5-one CAS: 127053-30-9 (1.06 g; 5.95 mmol) in methanol (12 ml) was added pyridine (1.53 ml; 19.04 mmol) followed by a portionwise addition of methoxyamine hydrochloride (1.59 g; 19.04 mmol). The reaction mixture was stirred at 20° C. for 16 h under nitrogen. The solvent was removed in vacuo to afford 1.28 g (100% of theory) of crude 6-fluoro-6,7,8,9-tetrahydrobenzocylohepten-5-one-O-methyl-oxime E/Z-mixture as a brown oil.
Workup
- customThe solvent was removed in vacuo
Sources & evidence
- ORD record
- ord-2817c7c4306e4ed2af1511ce13c51a9f
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08653003B2
Reaction notes
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