Hydrochloric Acid → HCID 22640019, compound

Participants

Reaction Steps

In analogy to the method described in example B1, 23.5 g (66 mmol) of (3-benzyloxybenzyl)(5-chloro-2,6-dimethylpyrimidin-4-yl)amine (from example A2) are reacted with 240 ml of 12.5N hydrochloric acid in 240 ml of ethanol. Extraction with ethyl acetate at a pH of 8 gives, after concentration, a solid residue which is extracted by stirring with water and dried. 9.03 g (52%) of the title compound are isolated as a beige crystallizate. m.p.: 194-197° C.

Provenance & Evidence