Hydrochloric Acid → HCID 22640019, compound

HRID 2415101Notes

Reaction equation

HRID 2415101 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH:23]=[CH:24][CH:25]=1)[CH2:12][NH:13][C:14]1[C:19]([Cl:20])=[C:18]([CH3:21])[N:17]=[C:16]([CH3:22])[N:15]=1)C1C=CC=CC=1.Cl>C(O)C>[Cl:20][C:19]1[C:14]([NH:13][CH2:12][C:11]2[CH:10]=[C:9]([OH:8])[CH:25]=[CH:24][CH:23]=2)=[N:15][C:16]([CH3:22])=[N:17][C:18]=1[CH3:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22640037HCID 22640037, compound

Product 1

HCID 22640019HCID 22640019, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In analogy to the method described in example B1, 23.5 g (66 mmol) of (3-benzyloxybenzyl)(5-chloro-2,6-dimethylpyrimidin-4-yl)amine (from example A2) are reacted with 240 ml of 12.5N hydrochloric acid in 240 ml of ethanol. Extraction with ethyl acetate at a pH of 8 gives, after concentration, a solid residue which is extracted by stirring with water and dried. 9.03 g (52%) of the title compound are isolated as a beige crystallizate. m.p.: 194-197° C.

Workup

  1. extractionExtraction with ethyl acetate at a pH of 8
  2. customgives
  3. concentrationafter concentration
  4. extractiona solid residue which is extracted
  5. customdried

Sources & evidence

ORD record
ord-bceb59fd7d12413eb46f3c232b474173
Source dataset
uspto-grants-2004_11
Patent number
US06818642B2

Reaction notes

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