Hydrochloric Acid → HCID 22640745, compound

HRID 2415126Notes

Reaction equation

HRID 2415126 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[CH:21]=[C:20]([O:22][CH3:23])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1)(C)(C)C.[ClH:25]>ClCCl.O1CCOCC1>[ClH:25].[ClH:25].[CH3:23][O:22][C:20]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=[C:12]([NH:11][CH2:10][CH2:9][CH2:8][NH2:7])[CH:21]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57437795[3-(4-Methoxyquinolin-2-ylamino)propyl]carbamic acid tert-butyl ester

Product 1

HCID 22640745HCID 22640745, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of [3-(4-methoxyquinolin-2-ylamino)propyl]carbamic acid tert-butyl ester (3.10 g, 9.35 mmol) in anhydrous dichloromethane (20 ml) was treated with 4N HCl in 1,4-dioxane (10 ml). It was stirred at ambient temperature for 2 hours then was evaporated under reduced pressure to give N′-(4-methoxyquinolin-2-yl)propane-1,3-diamine dihydrochloride (2.81 g, 99%) as a white solid. [M+H]+ 232.

Workup

  1. customthen was evaporated under reduced pressure

Sources & evidence

ORD record
ord-8d16d3f71dd04507b92ee356ac88b29c
Source dataset
uspto-grants-2004_11
Patent number
US06818655B2

Reaction notes

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