9-(4-Bromobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide → 9-{4-[4-(5-Chloro-2-methoxy-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide

HRID 2415156Notes

Reaction equation

HRID 2415156 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([O:15][CH3:16])=[C:7]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:8]=1.[F:17][C:18]([F:42])([F:41])[CH2:19][NH:20][C:21]([C:23]1([CH2:36][CH2:37][CH2:38][CH2:39]Br)[C:35]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:29]2[C:24]1=[CH:25][CH:26]=[CH:27][CH:28]=2)=[O:22]>>[F:17][C:18]([F:41])([F:42])[CH2:19][NH:20][C:21]([C:23]1([CH2:36][CH2:37][CH2:38][CH2:39][N:12]2[CH2:11][CH2:10][N:9]([C:7]3[CH:8]=[C:3]([Cl:2])[CH:4]=[CH:5][C:6]=3[O:15][CH3:16])[CH2:14][CH2:13]2)[C:35]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:29]2[C:24]1=[CH:25][CH:26]=[CH:27][CH:28]=2)=[O:22]

Participants

3

Reactant 2

HCID 105264379-(4-Bromobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamideHCID 242064191-(5-Chloro-2-methoxyphenyl)piperazine--hydrogen chloride (1/1)

Product 1

HCID 226401569-{4-[4-(5-Chloro-2-methoxy-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide

Procedure

Prepared analogously to Example 2 b from 1-(5-chloro-2-methoxy-phenyl)-piperazine hydrochloride and 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide.

Sources & evidence

ORD record
ord-43b652011c0e46de8af8ec84d0d868f7
Source dataset
uspto-grants-2004_11
Patent number
US06818644B1

Reaction notes

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