Trifluoroacetic acid → 1-(6-Phenyl-pyridin-2-yl)-piperazine

HRID 2415168Notes

Reaction equation

HRID 2415168 reaction equation
[C:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[CH:10]=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O)=O>ClCCl>[C:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[CH:10]=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68577637HCID 68577637, compound

Product 1

HCID 226401851-(6-Phenyl-pyridin-2-yl)-piperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 0.7 g (2.06 mmol) of tert.butyl 4-(6-phenyl-pyridin-2-yl)-piperazine-1-carboxylate and 3 ml of trifluoroacetic acid in 30 ml of dichloromethane is stirred for three hours at ambient temperature. The solvent is then distilled off, the residue is combined with water and made basic with sodium hydroxide solution. It is then extracted with dichloromethane and the organic phase is separated off and dried over sodium sulphate.

Workup

  1. distillationThe solvent is then distilled off
  2. extractionIt is then extracted with dichloromethane
  3. customthe organic phase is separated off
  4. dry with materialdried over sodium sulphate

Sources & evidence

ORD record
ord-bc06fdb1fa914bbab7af4e3ad94e33e1
Source dataset
uspto-grants-2004_11
Patent number
US06818644B1

Reaction notes

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