HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 241523Generated: October 30, 2026
Ethanol → 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzaldehyde-ethylsemicarbazone
https://huagongshe.com/reaction/241523
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl semicarbazide hydrochloride | HCID 86690409 | — |
| Reactant | 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzaldehyde | HCID 86691050 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzaldehyde-ethylsemicarbazone | HCID 123385650 | 93% |
Reaction Steps
A mixture of 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-chloro-benzaldehyde (121 mg, 0.29 mmol) and ethyl semicarbazide hydrochloride (60 mg 0.43 mmol) in ethanol (5 mL) and glacial acetic acid (0.1 mL) was heated at 70° C. for 4 h. Then, water was added and cooled, upon which a precipitate formed. The latter was collected by filtration and dried in vacuum to obtain the title compound (137 mg, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08653000B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-5bd3fa0d1fca4585bd89f76ba57d0160 |
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| Source note | uspto-grants-2014_02 |
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