4-Bromo-2-ethenyl-1-fluorobenzene → 4-Bromo-2-ethyl-1-fluorobenzene

HRID 2415256Notes

Reaction equation

HRID 2415256 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([CH:9]=[CH2:10])[CH:3]=1>C(OCC)(=O)C.[Pd]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([CH2:9][CH3:10])[CH:3]=1

Participants

4

Reactant 1

HCID 219339834-Bromo-2-ethenyl-1-fluorobenzene

Product 1

HCID 226410254-Bromo-2-ethyl-1-fluorobenzene

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The yellow oil from step A (2.8 g, 10 mmol) was dissolved in Ethyl acetate (200 mL). Palladium-on-carbon (10%, 250 mg) was added and the mixture was hydrogenated under 1 atmosphere until TLC showed complete reaction. The mixture was filtered and the filtrate was concentrated to give an oil. 2.4 g, 87%.

Workup

  1. customreaction
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate was concentrated
  4. customto give an oil

Sources & evidence

ORD record
ord-5c9659d2b24b40b89f0b8d48f5bfa4d3
Source dataset
uspto-grants-2004_11
Patent number
US06818663B2

Reaction notes

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