Bromine → 2-Bromo-1-(3-ethoxyphenyl)ethanone

HRID 2415261Notes

Reaction equation

HRID 2415261 reaction equation
NC(N)=S.[CH2:5]([O:7][C:8]1[CH:9]=[C:10]([C:14](=[O:16])[CH3:15])[CH:11]=[CH:12][CH:13]=1)[CH3:6].[Br:17]Br>>[Br:17][CH2:15][C:14]([C:10]1[CH:11]=[CH:12][CH:13]=[C:8]([O:7][CH2:5][CH3:6])[CH:9]=1)=[O:16]

Participants

4

Reactant 3

HCID 24408BromineHCID 2723790ThioureaHCID 37702501-(3-Ethoxyphenyl)ethanone

Product 1

HCID 226410062-Bromo-1-(3-ethoxyphenyl)ethanone

Procedure

This compound was prepared from resin-bound thiourea of Example 24 and 2-bromo-(3-ethoxyphehyl)-ethanone by the procedure used in Example 36. MS (ES) MH+=453. The 2-bromo-(3-ethoxyphenyl)-ethanone was prepared by treating 1-(3-ethoxy-phenyl)-ethanone (prepared in accordance with the procedure in J. Chem. Soc. Perkin Trans. 2:1996, 755-760) with bromine as in Example 20C.

Workup

  1. customprepared in accordance with the procedure in J

Sources & evidence

ORD record
ord-2a103c4c211c48989b7fa4bbd9802886
Source dataset
uspto-grants-2004_11
Patent number
US06818663B2

Reaction notes

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