HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-beta-carboline → HCID 12993019, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-beta-carboline | HCID 201172 | — |
| Reactant | 2-Chloro-5-(4-methylphenyl)pyrimidine | HCID 12993039 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Product | HCID 12993019 | HCID 12993019 | — |
Reaction Steps
Following the same procedure as outlined in Example 12, 1-(3,4-methylenedioxyphenyl)-2,3,4,9-tetrahydro-1H-β-carboline (2.19 g, 7.5 mmol) (prepared according to the process as disclosed in WO97/43287, Intermediate 7, page 24) and 2-chloro-5-(4-methylphenyl)pyrimidine (1.03 g, 5 mmol) in toluene (50 mL, anhydrous) and DBU (0.9 mL) were reacted to yield the product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06818646B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-bd37081555844328a27bd5149fca3294 |
| Source note | uspto-grants-2004_11 |