1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-beta-carboline → HCID 12993019, compound

HRID 2415362Notes

Reaction equation

HRID 2415362 reaction equation
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH:10]3[C:22]4[NH:21][C:20]5[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=5)[C:14]=4[CH2:13][CH2:12][NH:11]3)=[CH:4][C:3]=2[O:2]1.Cl[C:24]1[N:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][C:33]([CH3:36])=[CH:32][CH:31]=2)=[CH:26][N:25]=1>C1(C)C=CC=CC=1.C1CCN2C(=NCCC2)CC1>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH:10]3[C:22]4[NH:21][C:20]5[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=5)[C:14]=4[CH2:13][CH2:12][N:11]3[C:24]3[N:25]=[CH:26][C:27]([C:30]4[CH:35]=[CH:34][C:33]([CH3:36])=[CH:32][CH:31]=4)=[CH:28][N:29]=3)=[CH:4][C:3]=2[O:2]1

Participants

5

Reactant 2

HCID 2011721-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-beta-carbolineHCID 129930392-Chloro-5-(4-methylphenyl)pyrimidine

Product 1

HCID 12993019HCID 12993019, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneSolvent

Procedure

Following the same procedure as outlined in Example 12, 1-(3,4-methylenedioxyphenyl)-2,3,4,9-tetrahydro-1H-β-carboline (2.19 g, 7.5 mmol) (prepared according to the process as disclosed in WO97/43287, Intermediate 7, page 24) and 2-chloro-5-(4-methylphenyl)pyrimidine (1.03 g, 5 mmol) in toluene (50 mL, anhydrous) and DBU (0.9 mL) were reacted to yield the product as a white solid.

Workup

  1. customprepared
  2. customwere reacted

Sources & evidence

ORD record
ord-bd37081555844328a27bd5149fca3294
Source dataset
uspto-grants-2004_11
Patent number
US06818646B2

Reaction notes

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