HCID 10994934, compound → HCID 12993032, compound

HRID 2415377Notes

Reaction equation

HRID 2415377 reaction equation
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH:10]3[C:14]4[NH:15][C:16]5[CH:17]=[CH:18][CH:19]=[CH:20][C:21]=5[C:22](=[O:23])[C:13]=4[CH2:12][N:11]3[C:24]([C:26]3[O:27][C:28]([C:31]4[CH:36]=[CH:35][C:34]([N+:37]([O-])=O)=[CH:33][CH:32]=4)=[CH:29][CH:30]=3)=[O:25])=[CH:4][C:3]=2[O:2]1>[Pd]>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH:10]3[C:14]4[NH:15][C:16]5[CH:17]=[CH:18][CH:19]=[CH:20][C:21]=5[C:22](=[O:23])[C:13]=4[CH2:12][N:11]3[C:24]([C:26]3[O:27][C:28]([C:31]4[CH:32]=[CH:33][C:34]([NH2:37])=[CH:35][CH:36]=4)=[CH:29][CH:30]=3)=[O:25])=[CH:4][C:3]=2[O:2]1

Participants

3

Reactant 1

HCID 10994934HCID 10994934, compound

Product 1

HCID 12993032HCID 12993032, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1,2,3,4-Tetrahydro-3-(3,4-methylenedioxyphenyl)-2-[(5-(4-nitrophenyl))-furoyl]-9H-pyrrolo[3,4-b]quinolin-9-one (25 mg, 0.0479 mmol) (prepared as in Example 33) was stirred with 10% Pd on Carbon (5.1 mg, 0.00479 mmol) under 1 atm H2 at room temperature for 14 h. The solvent was evaporated and product isolated by preparative TLC as a yellow powder.

Workup

  1. customThe solvent was evaporated
  2. customproduct isolated by preparative TLC as a yellow powder

Sources & evidence

ORD record
ord-688bd89bc7df49ddaf514346d7fe9ac7
Source dataset
uspto-grants-2004_11
Patent number
US06818646B2

Reaction notes

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