Water → HCID 22641972, compound

HRID 2415447Notes

Reaction equation

HRID 2415447 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH:13]([CH3:17])[C:14]([NH2:16])=[O:15])[CH2:6][CH2:5]2.C(=O)([O-])[O-].[K+].[K+].[F:24][C:25]1[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=1[CH2:27]Br.O>CC(C)=O>[F:24][C:25]1[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=1[CH2:27][O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH:13]([CH3:17])[C:14]([NH2:16])=[O:15])[CH2:6][CH2:5]2

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 67968alpha-Bromo-o-fluorotolueneHCID 22641933HCID 22641933, compound

Product 1

HCID 22641972HCID 22641972, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-(6-Hydroxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-propionamide (50 mg, 0.213 mmol), was solved in dry acetone (1 mL) and potassium carbonate (38.3 mg, 0.276 mmol) was added followed by 2-fluorobenzyl bromide (42.36 mg, 0.224 mmol). The mixture was stirred overnight. Water was added and a precipitate appeared. The precipitated was filtrated and the title compound was obtained as a white solid (58 mg, 79%). MS: m/e=343.2 (M+H+).

Workup

  1. filtrationThe precipitated was filtrated

Sources & evidence

ORD record
ord-9e5f91b13f554c17a2bc8db66844bd5f
Source dataset
uspto-grants-2004_11
Patent number
US06818774B2

Reaction notes

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