反应详情

温度

60 °C

A mixture of 6-(3-fluoro-benzyloxy)-3,4-dihydro-2H-isoquinolin-1-one (1.2 g, 4.423 mmol) and lithium aluminum hydride (0.337 g, 8,84 mmol) in tetrahydrofuran (24 ml) was heated to 60° C. for 8 h. Water was added and an 15% aqueous solution of sodium hydroxide and the mixture was extracted with ethylacetate. After drying of the organic layer with MgSO4, filtration and evaporation, an oil was obtained (1.14 g, 99%). MS: m/e 258.0 (M+H+).

1. extractionan 15% aqueous solution of sodium hydroxide and the mixture was extracted with ethylacetate
2. dry with materialAfter drying of the organic layer with MgSO4, filtration and evaporation
3. customan oil was obtained (1.14 g, 99%)