HCID 70005743, compound → HCID 10405097, compound

HRID 2415459Notes

Reaction equation

HRID 2415459 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]1[CH:10]=[C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:8]=[CH:7][C:6]=1[CH2:20][NH:21][C@H:22]([C:24](=[O:26])[NH2:25])[CH3:23]>C1(C)C=CC=CC=1>[F:19][C:16]1[CH:15]=[CH:14][C:13]([CH2:12][O:11][C:9]2[CH:10]=[C:5]3[C:6](=[CH:7][CH:8]=2)[CH2:20][N:21]([C@@H:22]([CH3:23])[C:24]([NH2:25])=[O:26])[C:3](=[O:2])[CH2:4]3)=[CH:18][CH:17]=1

Participants

3

Reactant 1

HCID 70005743HCID 70005743, compound

Product 1

HCID 10405097HCID 10405097, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

[2-[(1(S)-Carbamoyl-ethylamino)-methyl]-5-(4-fluoro-benzyloxy)-phenyl]-acetic acid methyl ester (0.150 g, 0.401 mmol) is refluxed in toluene at 140° C. with a Deam-Stark trap to remove the methanol formed in the reaction. After 5 h the product is obtained. The toluene is removed by evaporation and the compound is crystallized in ether (0.115 g, 84%). MS: m/e=343.4 (M+H+).

Workup

  1. customto remove the methanol
  2. customformed in the reaction
  3. customAfter 5 h the product is obtained
  4. customThe toluene is removed by evaporation
  5. customthe compound is crystallized in ether (0.115 g, 84%)

Sources & evidence

ORD record
ord-55da47a625dd4fd1ae8e66a0f2964e93
Source dataset
uspto-grants-2004_11
Patent number
US06818774B2

Reaction notes

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