HCID 70005743, compound → HCID 10405097, compound

Participants

Reaction Steps

[2-[(1(S)-Carbamoyl-ethylamino)-methyl]-5-(4-fluoro-benzyloxy)-phenyl]-acetic acid methyl ester (0.150 g, 0.401 mmol) is refluxed in toluene at 140° C. with a Deam-Stark trap to remove the methanol formed in the reaction. After 5 h the product is obtained. The toluene is removed by evaporation and the compound is crystallized in ether (0.115 g, 84%). MS: m/e=343.4 (M+H+).

Provenance & Evidence