Picolyl chloride → HCID 22641302, compound

HRID 2415468Notes

Reaction equation

HRID 2415468 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][C:6]([OH:17])=[CH:7][CH:8]=2)[N:3]=1.[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[CH2:24]Cl>>[CH3:1][C:2]1[CH:11]=[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][C:6]([O:17][CH2:24][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][N:18]=3)=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 23393Picolyl chlorideHCID 1358041182-Methyl-4-pyrrolidin-1-yl-quinolin-7-ol

Product 1

HCID 22641302HCID 22641302, compound

Procedure

In analogy to example 6 there was prepared: on reaction of 2-methyl-4-pyrrolidin-1-yl-quinolin-7-ol with 2-picolyl choride, whereby the product was isolated as free base, 2-methyl-7-(pyridin-2-ylmethoxy)-4-pyrrolidin-1-yl-quinoline as a light brown solid. ISP mass spectrum, m/e: 320.4 (M+1 calculated for C20H21N3O: 320).

Workup

  1. customIn analogy to example 6 there was prepared

Sources & evidence

ORD record
ord-1ff48f01a7c243d8831e029c648f928f
Source dataset
uspto-grants-2004_11
Patent number
US06818767B2

Reaction notes

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