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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2415473Generated: November 1, 2026

3-(Chloromethyl)pyridine hydrochloride → 2-Methyl-7-(pyridin-3-ylmethoxy)-4-pyrrolidin-1-yl-quinoline

https://huagongshe.com/reaction/2415473

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Chloromethyl)pyridine hydrochlorideHCID 23394—
Reactant2-Methyl-4-pyrrolidin-1-yl-quinolin-7-olHCID 135804118—
Product2-Methyl-7-(pyridin-3-ylmethoxy)-4-pyrrolidin-1-yl-quinolineHCID 22641459—

Reaction Steps

In analogy to example 6 there was prepared: on reaction of 2-methyl-4-pyrrolidin-1-yl-quinolin-7-ol with 3-(chloromethyl)pyridine hydrochloride, whereby the product was isolated as free base, 2-methyl-7-(pyridin-3-ylmethoxy)-4-pyrrolidin-1-yl-quinoline as a red solid. ISP mass spectrum, m/e: 320.4 (M+1 calculated for C22H21N3O: 320).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06818767B2
Source datasetuspto-grants-2004_11
ORD IDord-6e22b4fb51b441d3b330747c69354f18
Source noteuspto-grants-2004_11