Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → 2-Methyl-7-(2-morpholin-4-yl-ethoxy)-4-pyrrolidin-1-yl-quinoline

HRID 2415475Notes

Reaction equation

HRID 2415475 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][C:6]([OH:17])=[CH:7][CH:8]=2)[N:3]=1.Cl.Cl[CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>>[CH3:1][C:2]1[CH:11]=[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][C:6]([O:17][CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)HCID 1358041182-Methyl-4-pyrrolidin-1-yl-quinolin-7-ol

Product 1

HCID 226413352-Methyl-7-(2-morpholin-4-yl-ethoxy)-4-pyrrolidin-1-yl-quinoline

Procedure

In analogy to example 6 there was prepared: on reaction of 2-methyl-4-pyrrolidin-1-yl-quinolin-7-ol with 4-(2-chloroethyl)-morpholine hydrochloride, whereby the product was isolated as free base, 2-methyl-7-(2-morpholin-4-yl-ethoxy)-4-pyrrolidin-1-yl-quinoline as a brown solid. ISP mass spectrum, m/e: 342.3 (M+1 calculated for C20H27N3O2: 342).

Workup

  1. customIn analogy to example 6 there was prepared

Sources & evidence

ORD record
ord-9e4cb439ff534d12adc32e1a5633595b
Source dataset
uspto-grants-2004_11
Patent number
US06818767B2

Reaction notes

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