HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → 2-Methyl-7-(2-morpholin-4-yl-ethoxy)-4-pyrrolidin-1-yl-quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Reactant | 2-Methyl-4-pyrrolidin-1-yl-quinolin-7-ol | HCID 135804118 | — |
| Product | 2-Methyl-7-(2-morpholin-4-yl-ethoxy)-4-pyrrolidin-1-yl-quinoline | HCID 22641335 | — |
Reaction Steps
In analogy to example 6 there was prepared: on reaction of 2-methyl-4-pyrrolidin-1-yl-quinolin-7-ol with 4-(2-chloroethyl)-morpholine hydrochloride, whereby the product was isolated as free base, 2-methyl-7-(2-morpholin-4-yl-ethoxy)-4-pyrrolidin-1-yl-quinoline as a brown solid. ISP mass spectrum, m/e: 342.3 (M+1 calculated for C20H27N3O2: 342).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06818767B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-9e4cb439ff534d12adc32e1a5633595b |
| Source note | uspto-grants-2004_11 |