n-(4,7-Dichloroquinolin-2-yl)benzamide → 2-Amino-4,7-dichloroquinoline

HRID 2415620노트

반응식

HRID 2415620 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[C:4]([NH:13]C(=O)C2C=CC=CC=2)[CH:3]=1>Cl>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[C:4]([NH2:13])[CH:3]=1

참가 물질

3

반응물 1

HCID 22641855n-(4,7-Dichloroquinolin-2-yl)benzamide

생성물 1

HCID 140674082-Amino-4,7-dichloroquinoline

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A mixture of example 289B (5.0 g, 15.8 mmol) and hydrochloric acid (22%, 150 mL) was heated to reflux for 24 hours, cooled to room temperature, filtered. Filtrate was basified with 50% sodium hydroxide. Pale green solid was collected by filtration, washed with large quantity of water and dried under vacuum. MS (ESI(+)Q1MS m/z 291 (M+H)+.

후처리

  1. temperatureto reflux for 24 hours
  2. filtrationfiltered
  3. filtrationPale green solid was collected by filtration
  4. washwashed with large quantity of water
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-c1206ec6a7d848469cd8ed2bfc280233
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06818772B2

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