Acetaminophen → Safapryn

Participants

Reaction Steps

320 mg of acetaminophen or aspirin (USP Powder, CAS-50-78-2), 175 mg of microfibrillated/powdered cellulose or microcrystalline cellulose (Avicel PH-102), and 5 mg of magnesium stearate were homogenously mixed and then compressed on a Carver Press using a 10-mm die and punches and a pressure of 4000 lbs and a dwell time of 1 min. The hardness and disintegration times of tablets are presented in Table 3.

Provenance & Evidence