Acetaminophen → Safapryn

HRID 2415631Notes

Reaction equation

[CH3:1][C:2]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1)=[O:3].[CH3:12][C:13]([O:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:21]=1[C:22]([OH:24])=[O:23])=[O:14].C([O-])(=O)CCCCCCCCCCCCCCCCC.[Mg+2].C([O-])(=O)CCCCCCCCCCCCCCCCC>>[CH3:1][C:2]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)=[O:3].[CH3:12][C:13]([O:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:21]=1[C:22]([OH:24])=[O:23])=[O:14]

Participants

Reactant 3

HCID 1983Acetaminophen

HCID 2244Aspirin

HCID 11177Magnesium Stearate

Product 1

HCID 83966Safapryn

Procedure

320 mg of acetaminophen or aspirin (USP Powder, CAS-50-78-2), 175 mg of microfibrillated/powdered cellulose or microcrystalline cellulose (Avicel PH-102), and 5 mg of magnesium stearate were homogenously mixed and then compressed on a Carver Press using a 10-mm die and punches and a pressure of 4000 lbs and a dwell time of 1 min. The hardness and disintegration times of tablets are presented in Table 3.

Workup

customa dwell time of 1 min

Sources & evidence

ORD record: ord-c60b91e4277b478cb62af7f64a48aac4
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06821531B2

Reaction notes

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