反应详情

To a solution of 2,5-difluorobenzaldehyde (0.765 mL, 7.04 mmol) in ethanol (15 mL) were added methyl 4-nitrobutyrate (0.901 mL, 7.04 mmol) and methylamine (7.04 mL, 14.07 mmol). The mixture was heated at reflux temperature overnight. After evaporation, the residue was purified by column chromatography (silica gel Biotage 40M) eluting with ethyl acetate/hexane (gradient from 40% to 60%) to give the title compound as the racemic trans isomer. LC-MS: 271.05 (M+1).

1. temperatureThe mixture was heated
2. temperatureat reflux temperature overnight
3. customAfter evaporation
4. customthe residue was purified by column chromatography (silica gel Biotage 40M)
5. washeluting with ethyl acetate/hexane (gradient from 40% to 60%)