反应详情

To a solution of methyl-3-aminosalicylate (3.34 grams, 20 mmol) in concentrated formic acid (20 mL) was added solid sodium formate (1.36 grams, 20 mmol, 1 eq.) and the resulting suspension stirred under reflux for 2 hours. The precipitate was filtered at room temperature and washed with water until neutral. After drying on air, 3.595 grams (92%) light brown crystals were collected. M+196, M−194.

1. temperatureunder reflux for 2 hours
2. filtrationThe precipitate was filtered at room temperature
3. washwashed with water until neutral
4. customAfter drying on air, 3.595 grams (92%) light brown crystals
5. customwere collected