反应详情

1-acetyl-4-(2,4-difluorobenzoyl)piperidine (5.6 g, 20.9 mmol) is added to 19 ml of 6N Hydrochloric acid and reflux for 5 hours. The mixture is evaporated to dryness under reduced pressure. The residue is added 20 ml of isopropanol, stirred, filtered, and dried to obtain 4.67 g of a product, with a yield of 85%.

1. temperaturereflux for 5 hours
2. customThe mixture is evaporated to dryness under reduced pressure
3. additionThe residue is added 20 ml of isopropanol
4. filtrationfiltered
5. customdried