Hydrochloric Acid → (2,4-Difluorophenyl)(piperidin-4-yl)methanone hydrochloride

HRID 241583Notes

Reaction equation

HRID 241583 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=[O:19])[C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=2[F:18])[CH2:6][CH2:5]1)(=O)C.[ClH:20]>>[ClH:20].[F:18][C:12]1[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:11]=1[C:10]([CH:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1)=[O:19]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 27407071-Acetyl-4-(2',4'-difluorobenzoyl)piperidine

Product 1

HCID 18759874(2,4-Difluorophenyl)(piperidin-4-yl)methanone hydrochlorideYield 85%

Procedure

1-acetyl-4-(2,4-difluorobenzoyl)piperidine (5.6 g, 20.9 mmol) is added to 19 ml of 6N Hydrochloric acid and reflux for 5 hours. The mixture is evaporated to dryness under reduced pressure. The residue is added 20 ml of isopropanol, stirred, filtered, and dried to obtain 4.67 g of a product, with a yield of 85%.

Workup

  1. temperaturereflux for 5 hours
  2. customThe mixture is evaporated to dryness under reduced pressure
  3. additionThe residue is added 20 ml of isopropanol
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-fc868c7b710d45439eefc1a7f0e2cec6
Source dataset
uspto-grants-2014_02
Patent number
US08653069B2

Reaction notes

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