Trifluoroacetic acid → HCID 59139971, compound

HRID 2415870Notes

Reaction equation

HRID 2415870 reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N:4]=[C:3]1[N:11]1[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]1.FC(F)(F)C(O)=O.C(=O)([O-])[O-].[Na+].[Na+]>ClCCl>[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N:4]=[C:3]1[N:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 10340Sodium CarbonateHCID 131724650HCID 131724650, compound

Product 1

HCID 59139971HCID 59139971, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 2.74 g (8.63 mmol) of tert.butyl 4-(3-methyl-3H-imidazo[4,5]pyridin-2-yl)-piperazin-1-carboxylate and 3.5 ml of trifluoroacetic acid in 50 ml of dichloromethane is stirred for 14 hours while refluxing. Dilute sodium carbonate is added cautiously, the organic phase is separated off and the aqueous phase is extracted with dichloromethane. The combined organic phases are dried over sodium sulphate.

Workup

  1. temperaturewhile refluxing
  2. customthe organic phase is separated off
  3. extractionthe aqueous phase is extracted with dichloromethane
  4. dry with materialThe combined organic phases are dried over sodium sulphate

Sources & evidence

ORD record
ord-14525d53df8846cb90bc00f428d2ab36
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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