HRID2415878

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78572

1H-Benzimidazole, 2-chloro-

C7H5ClN2

结构：O=C(NCC(F)(F)F)C1(CCCCN2CCNCC2)c2ccccc2-c2ccccc21

HCID22636285

未命名化合物

PRODUCTS

生成物

结构：O=C(NCC(F)(F)F)C1(CCCCN2CCN(c3nc4ccccc4[nH]3)CC2)c2ccccc2-c2ccccc21

HCID22636173

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21584144

Dichloromethane ethanol

C3H8Cl2O

CONDITIONS

反应条件

温度: 150 °C

PROCEDURE

实验过程

A mixture of 0.05 g (0.328 mmol) of 2-chloro-1H-benzimidazole and 0.21 g (0.487 mmol) of 9-(4-piperazin-1-yl-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide is heated to 150° C. for two hours. After cooling, the reaction mixture is dissolved in dichloromethane/ethanol. The product is purified by column chromatography on silica gel (eluant: dichloromethane/ethanol=20:1).

WORKUP

后处理

temperatureAfter cooling
customThe product is purified by column chromatography on silica gel (eluant: dichloromethane/ethanol=20:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-22f560c6311f420f9ac9a2bee2df59a4
来源数据集: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06821967B2
来源说明: uspto-grants-2004_11

反应 SMILES

Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[N:3]=1.[F:11][C:12]([F:41])([F:40])[CH2:13][NH:14][C:15]([C:17]1([CH2:30][CH2:31][CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[C:29]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[C:23]2[C:18]1=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:16]>ClCCl.C(O)C>[F:40][C:12]([F:11])([F:41])[CH2:13][NH:14][C:15]([C:17]1([CH2:30][CH2:31][CH2:32][CH2:33][N:34]2[CH2:35][CH2:36][N:37]([C:2]3[NH:6][C:5]4[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=4[N:3]=3)[CH2:38][CH2:39]2)[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=2[C:24]2[C:29]1=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:16]