関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Chlorobenzimidazole | HCID 78572 | — |
| 反応物 | 9-(4-piperazino-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide | HCID 22636285 | — |
| 溶媒 | Dichloromethane ethanol | HCID 21584144 | — |
| 生成物 | HCID 22636173 | HCID 22636173 | — |
反応手順
A mixture of 0.05 g (0.328 mmol) of 2-chloro-1H-benzimidazole and 0.21 g (0.487 mmol) of 9-(4-piperazin-1-yl-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide is heated to 150° C. for two hours. After cooling, the reaction mixture is dissolved in dichloromethane/ethanol. The product is purified by column chromatography on silica gel (eluant: dichloromethane/ethanol=20:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06821967B2 |
|---|
| 出典データセット | uspto-grants-2004_11 |
|---|
| ORD ID | ord-22f560c6311f420f9ac9a2bee2df59a4 |
|---|
| 出典メモ | uspto-grants-2004_11 |
|---|
