HRID2415880

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21

HCID10526437

9-(4-Bromobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide

C20H19BrF3NO

HCID12686427

未命名化合物

PRODUCTS

生成物

结构：O=C(NCC(F)(F)F)C1(CCCCN2CCN(c3cnc4c(Cl)cccc4n3)CC2)c2ccccc2-c2ccccc21

HCID22636234

未命名化合物

PROCEDURE

实验过程

Prepared analogously to Example 2 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide and 5-chloro-2-piperazin-1-yl-quinoxaline Melting point: 74° C. C32H31ClF3N5O (M=594.08) Calc.: molecular peak (M+H)+: 594/596. Found: molecular peak (M+H)+: 594/596.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-84682c1e2b5e4ff88a7c76cf68fa360e
来源数据集: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06821967B2
来源说明: uspto-grants-2004_11

反应 SMILES

[F:1][C:2]([F:26])([F:25])[CH2:3][NH:4][C:5]([C:7]1([CH2:20][CH2:21][CH2:22][CH2:23]Br)[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].[Cl:27][C:28]1[CH:37]=[CH:36][CH:35]=[C:34]2[C:29]=1[N:30]=[CH:31][C:32]([N:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1)=[N:33]2>>[F:1][C:2]([F:26])([F:25])[CH2:3][NH:4][C:5]([C:7]1([CH2:20][CH2:21][CH2:22][CH2:23][N:41]2[CH2:42][CH2:43][N:38]([C:32]3[CH:31]=[N:30][C:29]4[C:34](=[CH:35][CH:36]=[CH:37][C:28]=4[Cl:27])[N:33]=3)[CH2:39][CH2:40]2)[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6]