HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 8-Bromo-2-chloroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 8-Bromo-1,2-dihydroquinolin-2-one | HCID 10933094 | — |
| Product | 8-Bromo-2-chloroquinoline | HCID 10955755 | — |
Reaction Steps
A suspension of 2.8 g (12.49 mmol) of 8-bromo-1H-quinoline-2-one in 20 ml of phosphorus oxychloride is refluxed for 90 minutes and the reaction mixture is cooled and then added dropwise to 200 ml of water. The aqueous solution is made basic with concentrated ammonia solution, the precipitate formed is filtered off and washed with water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06821967B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-5a0e0f02466448bca837c883e86815a5 |
| Source note | uspto-grants-2004_11 |