Potassium Carbonate → HCID 69891395, compound

HRID 2415904Notes

Reaction equation

[CH3:1][CH:2]1[NH:7][CH2:6][CH2:5][N:4]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:3]1.Cl[C:16]1[CH:25]=[CH:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:1][CH:2]1[N:7]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]=2)[CH2:6][CH2:5][N:4]([C:8]([O:10][C:11]([CH3:13])([CH3:12])[CH3:14])=[O:9])[CH2:3]1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 119282-Chloroquinoline

HCID 2756810tert-Butyl 3-methylpiperazine-1-carboxylate

Product 1

HCID 69891395HCID 69891395, compound

Conditions

Temperature: 130 °C

Procedure

A reaction mixture of 1 g (4.99 mmol) of tert.butyl 3-methyl-piperazine-1-carboxylate, 0.588 g (3.6 mmol) of 2-chloroquinoline and 0.498 g (3.6 mmol) of potassium carbonate is heated to 130° C. for three hours. Then the solvent is distilled off. The residue is purified by column chromatography on silica gel (eluant: dichloromethane/ethanol/ammonia=30:1).

Workup

distillationThen the solvent is distilled off
customThe residue is purified by column chromatography on silica gel (eluant: dichloromethane/ethanol/ammonia=30:1)

Sources & evidence

ORD record: ord-71315000e46a4818a9bc8b0822d29621
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06821967B2

Reaction notes

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