HCID 69891395, compound → HCID 22636192, compound

HRID 2415905Notes

Reaction equation

HRID 2415905 reaction equation
[CH3:1][CH:2]1[N:7]([C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1>FC(F)(F)C(O)=O.ClCCl>[CH3:1][CH:2]1[CH2:3][NH:4][CH2:5][CH2:6][N:7]1[C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1

Participants

4

Reactant 1

HCID 69891395HCID 69891395, compound

Product 1

HCID 22636192HCID 22636192, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 0.15 g (0.458 mmol) of tert.butyl 3-methyl-4-quinolin-2-yl-piperazine-1-carboxylate in 1 ml of trifluoroacetic acid and 20 ml of dichloromethane is stirred for ten hours at ambient temperature. Then the solution is concentrated by evaporation, the residue is taken up in water and made alkaline with dilute sodium hydroxide solution. The aqueous phase is extracted with dichloromethane and the organic phase is dried over sodium sulphate.

Workup

  1. concentrationThen the solution is concentrated by evaporation
  2. extractionThe aqueous phase is extracted with dichloromethane
  3. dry with materialthe organic phase is dried over sodium sulphate

Sources & evidence

ORD record
ord-3e3ea62a95904ebea36939e3144b9595
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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