反应详情

1-bromo-4-chloro-butane (3.4 g, 20 mmol), anhydrous potassium carbonate powder (4.14 g, 30 mmol) and 7-hydroxy-3,4-dihydro-2(1H)-quinolinone (1.63 g, 10 mmol) are added to 10 ml of acetone and reflux for 24 hours. The reaction solution is evaporated to dryness and dispersed with 20 ml of dichloromethane and 20 ml of water respectively. The organic layer is extracted with water (20 ml×2) and saturated saline (20 ml) successively, dried over anhydrous magnesium sulfate, and evaporated to dryness to obtain a light yellow powder. The powder is slurried in n-hexane (20 ml×3), filtered, and dried to obtain 1.98 g of 7-(4-chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone, with a yield of 78%.

1. temperaturereflux for 24 hours
2. customThe reaction solution is evaporated to dryness
3. additiondispersed with 20 ml of dichloromethane and 20 ml of water respectively
4. extractionThe organic layer is extracted with water (20 ml×2) and saturated saline (20 ml) successively
5. dry with materialdried over anhydrous magnesium sulfate
6. customevaporated to dryness
7. customto obtain a light yellow powder
8. filtrationfiltered
9. customdried