Hexahydro-1,4-diazepine → HCID 22636225, compound

HRID 2415915Notes

Reaction equation

HRID 2415915 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH:12]1[CH2:18][CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>ClCCl.C(O)C.N>[N:12]1([C:2]2[N:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH2:18][CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 740542-Chloroquinazoline

Product 1

HCID 22636225HCID 22636225, compound

Reagents, catalysts & solvents 1

HCID 22609213HCID 22609213, compoundSolvent

Conditions

Temperature
140 °C

Procedure

A reaction mixture of 2 g (12.1 mmol) of 2-chloroquinazoline and 3.65 g (36.45 mmol) of [1.4]diazepan is stirred for one hour at 140° C. The cooled reaction mixture is dissolved in dichloromethane/ethanol/ammonia. The product is purified by column chromatography on silica gel (eluant: dichloromethane/ethanol/ammonia=35:1:0.1).

Workup

  1. customThe cooled reaction mixture
  2. customThe product is purified by column chromatography on silica gel (eluant: dichloromethane/ethanol/ammonia=35:1:0.1)

Sources & evidence

ORD record
ord-72a5e3a40054464cbfe6d996964d2d46
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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