HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2415915Generated: November 2, 2026
Hexahydro-1,4-diazepine → HCID 22636225, compound
https://huagongshe.com/reaction/2415915
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hexahydro-1,4-diazepine | HCID 68163 | — |
| Reactant | 2-Chloroquinazoline | HCID 74054 | — |
| Solvent | HCID 22609213 | HCID 22609213 | — |
| Product | HCID 22636225 | HCID 22636225 | — |
Reaction Steps
A reaction mixture of 2 g (12.1 mmol) of 2-chloroquinazoline and 3.65 g (36.45 mmol) of [1.4]diazepan is stirred for one hour at 140° C. The cooled reaction mixture is dissolved in dichloromethane/ethanol/ammonia. The product is purified by column chromatography on silica gel (eluant: dichloromethane/ethanol/ammonia=35:1:0.1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06821967B2 |
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| Source dataset | uspto-grants-2004_11 |
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| ORD ID | ord-72a5e3a40054464cbfe6d996964d2d46 |
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| Source note | uspto-grants-2004_11 |
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