反应详情

温度

125 °C

3-chloro-(1,2-benzisothiazole) (14 g, 200 mmol) and anhydrous piperazine (6.8 g, 40 mmol) are placed in an egg type flask and heated at 125° C. for 24 hours. After completion of reaction, 52 ml of an ice-water mixture is added for quenching the reaction. The mixture is further added with 3.2 g of 50% NaOH solution, stirred 5 minutes and extracted with CH2Cl2 (50 ml×3). The organic layer is washed with an ice-water mixture (50 ml×2) and saturated saline (50 ml×2), and dried over anhydrous MgSO4 to obtain 4-(1,2-benzisothiazol-3-yl)-1-piperazine.

1. additionis added
2. customfor quenching
3. customthe reaction
4. extractionextracted with CH2Cl2 (50 ml×3)
5. washThe organic layer is washed with an ice-water mixture (50 ml×2) and saturated saline (50 ml×2)
6. dry with materialdried over anhydrous MgSO4