1-methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole → 9-{4-[4-(1-methyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide

HRID 2415928Notes

Reaction equation

HRID 2415928 reaction equation
[F:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][NH:7][C:8]([C:10]2([CH2:23][CH2:24][CH2:25][CH2:26]Br)[C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[O:9])=[CH:4][CH:3]=1.[CH3:30][N:31]1[C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=2[N:33]=[C:32]1[N:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1>>[F:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][NH:7][C:8]([C:10]2([CH2:23][CH2:24][CH2:25][CH2:26][N:43]3[CH2:44][CH2:45][N:40]([C:32]4[N:31]([CH3:30])[C:35]5[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=5[N:33]=4)[CH2:41][CH2:42]3)[C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6675511-methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazoleHCID 226362389-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamide

Product 1

HCID 226362289-{4-[4-(1-methyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide

Procedure

Prepared analogously to Example 1 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamide and 1-methyl-2-piperazin-1-yl-1H-benzimidazole.

Sources & evidence

ORD record
ord-d84e51c4987449548cd297c66458690e
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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