HCID 22636218, compound → HCID 22636314, compound

HRID 2415977Notes

Reaction equation

HRID 2415977 reaction equation
C[O:2][C:3]([CH2:5][CH2:6][NH:7][C:8]([C:10]1([CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[CH2:32][CH2:31][N:30]([C:33]3[CH:42]=[CH:41][C:40]4[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=4)[N:34]=3)[CH2:29][CH2:28]2)[C:22]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:16]2[C:11]1=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:9])=[O:4]>[OH-].[Na+].CO>[C:3]([CH2:5][CH2:6][NH:7][C:8]([C:10]1([CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[CH2:28][CH2:29][N:30]([C:33]3[CH:42]=[CH:41][C:40]4[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=4)[N:34]=3)[CH2:31][CH2:32]2)[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=2[C:17]2[C:22]1=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:9])([OH:4])=[O:2]

Participants

4

Reactant 1

HCID 22636218HCID 22636218, compound

Product 1

HCID 22636314HCID 22636314, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of 0.08 g (0.142 mmol) of 9-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic acid-(2-methoxycarbonyl-ethyl)-amide in 2 ml of 2N sodium hydroxide solution and 35 ml of methanol is stirred for 14 hours at ambient temperature. Then the mixture is concentrated by evaporation, diluted with water and adjusted to a pH of 5 with 1N hydrochloric acid. The precipitate formed is filtered off.

Workup

  1. concentrationThen the mixture is concentrated by evaporation
  2. additiondiluted with water
  3. customThe precipitate formed
  4. filtrationis filtered off

Sources & evidence

ORD record
ord-e67f2e7795eb423a9a4bd05936ea24f3
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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