9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-3,4-difluoro-benzylamide → 9-[4-(cis-2,6-dimethyl-4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-3,4-difluoro-benzylamide

HRID 2415978Notes

Reaction equation

HRID 2415978 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][C:29]=1[F:30])[CH2:5][NH:6][C:7]([C:9]1([CH2:22][CH2:23][CH2:24][CH2:25]Br)[C:21]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[C:15]2[C:10]1=[CH:11][CH:12]=[CH:13][CH:14]=2)=[O:8].[CH3:31][C@H:32]1[NH:37][C@@H:36]([CH3:38])[CH2:35][N:34]([C:39]2[CH:48]=[CH:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[N:40]=2)[CH2:33]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][C:29]=1[F:30])[CH2:5][NH:6][C:7]([C:9]1([CH2:22][CH2:23][CH2:24][CH2:25][N:37]2[C@H:36]([CH3:38])[CH2:35][N:34]([C:39]3[CH:48]=[CH:47][C:46]4[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=4)[N:40]=3)[CH2:33][C@@H:32]2[CH3:31])[C:21]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[C:15]2[C:10]1=[CH:11][CH:12]=[CH:13][CH:14]=2)=[O:8]

Participants

3

Reactant 2

HCID 226361939-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-3,4-difluoro-benzylamideHCID 698931002-(cis-3,5-Dimethyl-piperazin-1-yl)-quinoline

Product 1

HCID 235268479-[4-(cis-2,6-dimethyl-4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-3,4-difluoro-benzylamide

Procedure

Prepared analogously to Example 2 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-3,4-difluoro-benzylamide and 2-(cis-3,5-dimethyl-piperazin-1-yl)-quinoline.

Sources & evidence

ORD record
ord-4ba933b999b54434a426a46cf86842ca
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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