1-methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole → 9-{4-[4-(1-methyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-xanthene-9-carboxylic Acid-(2,2,2-trifluoro-ethyl)-amide

HRID 2415982Notes

Reaction equation

HRID 2415982 reaction equation
[F:1][C:2]([F:27])([F:26])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23][CH2:24]Br)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].[CH3:28][N:29]1[C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=2[N:31]=[C:30]1[N:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1>>[F:1][C:2]([F:27])([F:26])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23][CH2:24][N:41]2[CH2:42][CH2:43][N:38]([C:30]3[N:29]([CH3:28])[C:33]4[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=4[N:31]=3)[CH2:39][CH2:40]2)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6]

Participants

3

Reactant 2

HCID 6675511-methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazoleHCID 221802034-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl bromide

Product 1

HCID 226363429-{4-[4-(1-methyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-xanthene-9-carboxylic Acid-(2,2,2-trifluoro-ethyl)-amide

Procedure

Prepared analogously to Example 1 from 9-(4-bromo-butyl)-9H-xanthene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide and 1-methyl-2-piperazin-1-yl-1H-benzimidazole.

Sources & evidence

ORD record
ord-5357934efe7c41d28aa9fe2b36952087
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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