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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2415982Generated: October 30, 2026

1-methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole → 9-{4-[4-(1-methyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-xanthene-9-carboxylic Acid-(2,2,2-trifluoro-ethyl)-amide

https://huagongshe.com/reaction/2415982

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazoleHCID 667551—
Reactant4-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl bromideHCID 22180203—
Product9-{4-[4-(1-methyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-xanthene-9-carboxylic Acid-(2,2,2-trifluoro-ethyl)-amideHCID 22636342—

Reaction Steps

Prepared analogously to Example 1 from 9-(4-bromo-butyl)-9H-xanthene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide and 1-methyl-2-piperazin-1-yl-1H-benzimidazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06821967B2
Source datasetuspto-grants-2004_11
ORD IDord-5357934efe7c41d28aa9fe2b36952087
Source noteuspto-grants-2004_11