HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → 2-[5-(4-Cyanophenyl)-1-benzofuran-2-yl]ethyl 4-methylbenzenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 4-[2-(2-Hydroxyethyl)-1-benzofuran-5-yl]benzonitrile | HCID 11482439 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-[5-(4-Cyanophenyl)-1-benzofuran-2-yl]ethyl 4-methylbenzenesulfonate | HCID 11711405 | — |
Reaction Steps
reacting 4-[2-(2-hyd roxyethyl)-1-benzofuran-5-yl]benzonitrile with para-toluenesulfonyl chloride and N,N-dimethylaminopyridine, in the presence of a base, such as triethylamine, to provide 2-[5-(4-cyanophenyl)-1-benzofuran-2-yl]ethyl 4-methylbenzenesulfonate; and
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06822101B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-14a1aad03a834693bdc733261db9038a |
| Source note | uspto-grants-2004_11 |