反应详情

To a dimethylformamide solution (49.5 ml) of 1-ethynyl-1-hydroxycyclopentane (5.45 g, 49.5 mmol) were added imidazole (6.74 g, 99.0 mmol) and triethylchlorosilane (9.97 ml, 59.4 mmol) at room temperature, followed by stirring for 30 minutes. The reaction solution was added to a mixture of n-hexane and a saturated aqueous sodium bicarbonate solution, and the organic layer was separated. The aqueous layer was extracted with hexane, and the organic layers were combined, washed with a saturated aqueous sodium bicarbonate solution and dried over anhydrous magnesium sulfate. After filtration, the filtrate was evaporated under reduced pressure to give the title compound (9.26 g).

1. customa saturated aqueous sodium bicarbonate solution, and the organic layer was separated
2. extractionThe aqueous layer was extracted with hexane
3. washwashed with a saturated aqueous sodium bicarbonate solution
4. dry with materialdried over anhydrous magnesium sulfate
5. filtrationAfter filtration
6. customthe filtrate was evaporated under reduced pressure