Lithium Hydroxide → HCID 22638581, compound

HRID 2416193Notes

Reaction equation

HRID 2416193 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[C:11]([CH2:13][C:14]([O:16]C)=[O:15])[N:12]=2)=[CH:4][CH:3]=1.[Li+].[OH-]>>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 22638599HCID 22638599, compound

Product 1

HCID 22638581HCID 22638581, compound

Procedure

This material was prepared according to the procedure described for Example 24(b) using methyl 2-[2-(6-methyl-3-pyridyl)-1,3-thiazol-4-yl]acetate (Step a, 0.5 g, 2.0 mmol) and LiOH (2 N, 5.0 mL). The product was filtered and washed successively with CH2Cl2, EtOAc, and hexanes to afford the title compound as a white solid. MS m/z: 235 (M+1). Calc'd for C11H10N2O2S: 234.05.

Workup

  1. customThis material was prepared
  2. filtrationThe product was filtered
  3. washwashed successively with CH2Cl2, EtOAc, and hexanes

Sources & evidence

ORD record
ord-8e75630d351b47dea77836c787cc8543
Source dataset
uspto-grants-2004_11
Patent number
US06822097B1

Reaction notes

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