HCID 17937292, compound → HCID 17937358, compound

HRID 2416298Notes

Reaction equation

HRID 2416298 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:16]=[C:17]([O:20][CH2:21][CH3:22])[C:18]=1I)[CH2:7][C:8]1[C:9]([NH2:15])=[N:10][C:11]([NH2:14])=[N:12][CH:13]=1)[CH3:2].[CH3:23][O:24][C:25]1[CH:26]=[C:27](OB(O)O)[CH:28]=[CH:29][C:30]=1[O:31][CH3:32].C(OC1C=C(C=C(OCC)C=1C1C=CSC=1)CC1C(N)=NC(N)=NC=1)C>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH2:7][C:8]2[C:9]([NH2:15])=[N:10][C:11]([NH2:14])=[N:12][CH:13]=2)[CH:16]=[C:17]([O:20][CH2:21][CH3:22])[C:18]=1[C:28]1[CH:27]=[CH:26][C:25]([O:24][CH3:23])=[C:30]([O:31][CH3:32])[CH:29]=1)[CH3:2]

Participants

4

Reactant 3

HCID 17937292HCID 17937292, compoundHCID 226369195-(3,5-Diethoxy-4-iodo-benzyl)-pyrimidine-2,4-diamineHCID 226370253,4-Dimethoxyphenylboric acid

Product 1

HCID 17937358HCID 17937358, compound

Procedure

Starting from 5-(3,5-diethoxy-4-iodo-benzyl)-pyrimidine-2,4-diamine (example 1) (414 mg; 1.0 mmol) and 3,4-dimethoxy-phenyl-boric acid (363 mg; 2.0 mmol), 328 mg (77%) 5-(3,5-diethoxy-4-thiophen-3-yl-benzyl)-pyrimidine-2,4-diamine [sic] are obtained as a yellowish powder after recrystallization from methanol.

Workup

  1. customare obtained as a yellowish powder
  2. customafter recrystallization from methanol

Sources & evidence

ORD record
ord-8349e1831abd4f29a678e8cce91ce915
Source dataset
uspto-grants-2004_11
Patent number
US06821980B1

Reaction notes

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