Butane-2-sulfonyl chloride → Butane-2-sulphonic acid 3'-amino-4-(2,4-diamino-pvrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-yl ester

HRID 2416320Notes

Reaction equation

HRID 2416320 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[C:9]([OH:26])=[CH:10][C:11]([CH2:17][C:18]3[C:19]([NH2:25])=[N:20][C:21]([NH2:24])=[N:22][CH:23]=3)=[CH:12][C:13]=2[O:14][CH2:15][CH3:16])[CH:5]=[CH:6][CH:7]=1.[CH:27]([S:31](Cl)(=[O:33])=[O:32])([CH2:29][CH3:30])[CH3:28]>>[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[C:13]([O:14][CH2:15][CH3:16])=[CH:12][C:11]([CH2:17][C:18]3[C:19]([NH2:25])=[N:20][C:21]([NH2:24])=[N:22][CH:23]=3)=[CH:10][C:9]=2[O:26][S:31]([CH:27]([CH2:29][CH3:30])[CH3:28])(=[O:33])=[O:32])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 2757336Butane-2-sulfonyl chlorideHCID 226369793'-Amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-ol

Product 1

HCID 17937242Butane-2-sulphonic acid 3'-amino-4-(2,4-diamino-pvrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-yl esterYield 67.4%

Procedure

Starting from 3′-amino-4-(2,4-diamino-pyrimidin-5-ylmethyl)-6-ethoxy-biphenyl-2-ol (176 mg; 0.50 mmol) and sec-butyl-sulphonyl chloride (94 mg; 0.60 mmol), 159 mg of the title compound are isolated as a white solid.

Sources & evidence

ORD record
ord-c798dad9aaa1482c8ab1f7adcd2829fb
Source dataset
uspto-grants-2004_11
Patent number
US06821980B1

Reaction notes

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