反应详情

5-(3-Ethoxy-5-hydroxy-4-iodo-benzyl)-pyrimidine-2,4-diamine (see example 32 stage a)) (5.9 g; 15.28 mmol) is dissolved in dimethylformamide (150 ml), and potassium tert-butylate (2.57 g; 22.92 mmol) is added. Propane-2-sulphonyl chloride (2.56 ml; 22.92 mmol) is added at 0° C. The mixture is then stirred for one hour at room temperature. The reaction mixture is evaporated and the residue is chromatographed over silica gel with methylene chloride/methanol (19/1) and 0.5% ammonia. The pure fractions are combined and the solvent is evaporated off.

1. customThe reaction mixture is evaporated
2. customthe residue is chromatographed over silica gel with methylene chloride/methanol (19/1) and 0.5% ammonia
3. customthe solvent is evaporated off