Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → HCID 22636910, compound

HRID 2416340Notes

Reaction equation

HRID 2416340 reaction equation
[CH:1]1([CH2:4]OC2C=C(CC3C(N)=NC(N)=NC=3)C=C(OCC)C=2C2C=CC(O)=CC=2)[CH2:3][CH2:2]1.Cl.ClCCN1CCOCC1.C1(CO[C:46]2[CH:51]=[C:50]([CH2:52][C:53]3[C:54]([NH2:60])=[N:55][C:56]([NH2:59])=[N:57][CH:58]=3)[CH:49]=[C:48]([O:61][CH2:62][CH3:63])[C:47]=2[C:64]2[CH:69]=[CH:68][C:67]([O:70][CH2:71][CH2:72][N:73]3[CH2:78][CH2:77][O:76][CH2:75][CH2:74]3)=[CH:66][CH:65]=2)CC1>>[CH:1]1([CH2:4][C:46]2[CH:51]=[C:50]([CH2:52][C:53]3[C:54]([NH2:60])=[N:55][C:56]([NH2:59])=[N:57][CH:58]=3)[CH:49]=[C:48]([O:61][CH2:62][CH3:63])[C:47]=2[C:64]2[CH:65]=[CH:66][C:67]([O:70][CH2:71][CH2:72][N:73]3[CH2:74][CH2:75][O:76][CH2:77][CH2:78]3)=[CH:68][CH:69]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)HCID 22636882HCID 22636882, compoundHCID 22637022HCID 22637022, compound

Product 1

HCID 22636910HCID 22636910, compound

Procedure

Starting from 2′-cyclopropylmethoxy-4′-(2,4-diamino-pyrimidin-5-ylmethyl)-6′ethoxy-biphenyl-4-ol (example 8h) (300 mg; 0.74 mmol) and 4-(2-chloroethyl)-morpholine hydrochloride (170 mg; 0.89 mmol), 129 mg (25%) 5-[2-cyclopropylmethoxy-6-ethoxy-4′-(2-morpholin-4-yl-ethoxy)-biphenyl-4-ylmethyl]-pyrimidine-2,4-diamine are obtained as a colourless powder.

Workup

  1. customare obtained as a colourless powder

Sources & evidence

ORD record
ord-32099499b39343ae8b1baf4827c048e1
Source dataset
uspto-grants-2004_11
Patent number
US06821980B1

Reaction notes

Loading…